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All the tools you need to analyse your miRNAs. Home. Overview. Tools4miRs is a first, manually curated platform gathering at the present over 170 methods for the broadly-defined miRNA analysis. All tools in Tools4miRs are classified in the four general and seven more detailed categories.

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The latter, termed a miRNA:miRNA interaction, is a form of self-regulation. In this Review, we discuss the three main modes of miRNA:miRNA regulation: direct, indirect and global interactions, and their implications in cancer biology.

Using miRNA extracted from L1CAM immunoaffinity purified extracellular vesicles (neural-enriched extracellular vesicles or NEE), we thrice replicated an 8-miRNA fingerprint diagnostic of ALS, which includes the miRNA species and direction of regulation.

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miRNA dosage control occurs at different steps of miRNA biogenesis in various physiological contexts. Dysregulation of global miRNA dosage contributes to cancer, embryo death, and neurological diseases. Artificial manipulation of global miRNA dosage provides a novel approach to treat human diseases.

In cancer, they can act as a tumor suppressor or oncomiR depending on the cell type. Studies have shown that miRNA-based therapy, either by inhibiting an oncomiR or by inducing a tumor suppressor, is effective in cancer treatment.

Download scientific diagram | Quantitatively additive detection of miRNA activity by a synthetic five-slot mRNA. (A) The design of a synthetic mRNA that contains five slots for miRNA target ...

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